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KMID : 1123920120260050699
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 5 p.699 ~ p.706
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Protective Effects of Younggyechulgam-tang in Cisplatin-induced Ototoxicity
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Jeon Ho-Seong
Park Rae-Gil
So Hong-Seob
Chong Myong-Soo
Lee Su-Kyung
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Abstract
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The water extract of Younggyechulgam-tang (YGCGT) has been traditionally used in treatment of tinnitus in Oriental Medicine. However, little is known about the mechanism by which YGCGT rescues ototoxicity. The purpose of the present study is to investigate the protective effect of YGCGT against cisplatin-induced toxicity in HEI-OC1 auditory cells, organotypic cultures of cochlear explants from three-day postnatal rats (P3). Pretreatment with YGCGT ameliorated apoptotic death induced by cisplatin in HEI-OC1 cells and organotypic cultures of Corti’s organ. YGCGT pretreatment also significantly suppressed cisplatin-induced increases in intracellular reactive oxygen species (ROS). Treatment with YGCGT resulted in an increased expression of HO-1 and Bcl-2. These results suggest that YGCGT induced HO-1 signaling pathway, which ultimately prevents free radical stresses from cisplatin and further contributes to protect auditory sensory hair cells from free radicals produced by cisplatin.
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KEYWORD
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younggyechulgam-tang, cisplatin, ototoxicity
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